Durability of protection after 5 doses of acellular pertussis vaccine among 5-9 year old children in King County, Washington.

ABSTRACT:

Purpose

Waning of immunity after vaccination with the acellular Pertussis (aP) vaccine has been proposed as one of the main reasons for pertussis resurgence in the US. In this study, we estimated time-varying vaccine effectiveness after 5 doses of aP vaccine.

Methods

We conducted a retrospective cohort study among children 5-9 years old (born between 2008 and 2012) living in King County, Washington, USA, who participated in the Washington State Immunization Information System. We estimated time-varying vaccine effectiveness after 5 doses of aP using smoothed scaled Schoenfeld residuals obtained from fitting Cox proportional hazards models to the data as well as piecewise constant Poisson regression.

Results

There were 55 pertussis cases in this cohort, of whom 22 (40%

SUBMITTER: Rane MS 

PROVIDER: S-EPMC9665886 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature