Ontology highlight
ABSTRACT:
SUBMITTER: Nakayama A
PROVIDER: S-EPMC9665902 | biostudies-literature | 2023 Jan
REPOSITORIES: biostudies-literature
Nakayama Akiko A Roquid Kenneth Anthony KA Iring András A Strilic Boris B Günther Stefan S Chen Min M Weinstein Lee S LS Offermanns Stefan S
The Journal of experimental medicine 20221114 1
Within the tumor microenvironment, tumor cells and endothelial cells regulate each other. While tumor cells induce angiogenic responses in endothelial cells, endothelial cells release angiocrine factors, which act on tumor cells and other stromal cells. We report that tumor cell-derived adrenomedullin has a pro-angiogenic as well as a direct tumor-promoting effect, and that endothelium-derived CC chemokine ligand 2 (CCL2) suppresses adrenomedullin-induced tumor cell proliferation. Loss of the en ...[more]