Saikosaponin-d Attenuates Hashimoto's Thyroiditis by Regulating Macrophage Polarization.

ABSTRACT:

Objective

Hashimoto's thyroiditis (HT) is one of the most common clinical autoimmune diseases. Recent studies have found that HT pathogenesis is associated with macrophage polarization. Saikosaponin-d (SSd) is an active component in the Chinese medicine Bupleurum, which has anti-inflammatory and immunomodulatory effects. The purpose of this study was to verify the therapeutic effect of SSd on HT and to investigate the regulatory effect of SSd on macrophage polarization in HT.

Methods

Network pharmacology analysis was used to predict the relevant targets and signaling pathways of SSd for HT treatment. The therapeutic effect of SSd on HT model mice and the effect on macrophage polarization were detected by animal experiment.

Results

Network pharmacological analysis show

SUBMITTER: Du P 

PROVIDER: S-EPMC9666046 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature