Weifuchun alters tongue flora and decreases serum trefoil factor I levels in gastric intestinal metaplasia: A CONSORT-compliant article.

ABSTRACT:

Objective

To explore the molecular mechanisms of Weifuchun in the treatment of gastric intestinal metaplasia (GIM), we designed a preclinical pilot study to examine potential markers of disease progression based on alterations in the tongue flora.

Methods

Total 27 patients with GIM were treated with Weifuchun for 4 weeks and 26 volunteers as controls. Tongue coating bacteria were profiled using 16S rDNA high-throughput sequencing. Serum pepsinogen I and II levels were detected using the latex immunoturbidimetric assay. The levels of serum trefoil factor I was detected by ELISA. Microplate-based quantification was used to detect serum total bile acid (TBA).

Results

After treatment, the relative abundance of 4 dominant tongue coating genera (Granulicatella, Gemella, Lac

SUBMITTER: Hua Z 

PROVIDER: S-EPMC9666156 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature