Expression of alternative transcription factor 4 mRNAs and protein isoforms in the developing and adult rodent and human tissues.

ABSTRACT: Transcription factor 4 (TCF4) belongs to the class I basic helix-loop-helix family of transcription factors (also known as E-proteins) and is vital for the development of the nervous system. Aberrations in the TCF4 gene are associated with several neurocognitive disorders such as schizophrenia, intellectual disability, post-traumatic stress disorder, depression, and Pitt-Hopkins Syndrome, a rare but severe autism spectrum disorder. Expression of the human TCF4 gene can produce at least 18 N-terminally distinct protein isoforms, which activate transcription with different activities and thus may vary in their function during development. We used long-read RNA-sequencing and western blot analysis combined with the analysis of publicly available short-read RNA-sequencing data to

SUBMITTER: Sirp A 

PROVIDER: S-EPMC9666405 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature