Ontology highlight
ABSTRACT:
SUBMITTER: Branco MA
PROVIDER: S-EPMC9666429 | biostudies-literature | 2022 Nov
REPOSITORIES: biostudies-literature
Branco Mariana A MA Dias Tiago P TP Cabral Joaquim M S JMS Pinto-do-Ó Perpetua P Diogo Maria Margarida MM
Nature communications 20221115 1
The epicardium, the outer epithelial layer that covers the myocardium, derives from a transient organ known as pro-epicardium, crucial during heart organogenesis. The pro-epicardium develops from lateral plate mesoderm progenitors, next to septum transversum mesenchyme, a structure deeply involved in liver embryogenesis. Here we describe a self-organized human multilineage organoid that recreates the co-emergence of pro-epicardium, septum transversum mesenchyme and liver bud. Additionally, we st ...[more]