Lung CCR6^-CXCR3^- type 2 helper T cells as an indicator of progressive fibrosing interstitial lung diseases.

ABSTRACT: Progressive fibrosing interstitial lung diseases (PF-ILDs) have a poor prognosis and may be resistant to corticosteroids and/or immunosuppressants, but antifibrotic therapies such as nintedanib and pirfenidone have been shown to slow the deterioration of lung function. The aim of this study was to identify the characteristic cellular profile of bronchoalveolar lavage fluid at diagnostic bronchoscopy for predicting PF-ILDs, defined as fibrotic diseases on chest high-resolution computed tomography with more than a 5% relative decline in the percent predicted value of forced vital capacity (FVC) over 6 months. The proportions of inflammatory cells, CCR6^-CXCR3^- T helper type 2 (Th2) cells among conventional CD4⁺ T cells in bronchoalveolar lavage fluid (BALF) an

SUBMITTER: Tsukuda TK 

PROVIDER: S-EPMC9666512 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature