The role of peak serum estradiol level in the prevention of multiple pregnancies in gonadotropin stimulated intrauterine insemination cycles.

ABSTRACT: The objective was to assess whether the measurement of serum estradiol (E₂) level on trigger day in controlled ovarian stimulation with intrauterine insemination (COS-IUI) cycles helps lower the multiple pregnancy (MP) rate. We performed a unicentric observational study. We included all patients who underwent COS-IUI and had a subsequent clinical pregnancy (CP) between 2011 and 2019. Our main outcome measure was the area under Receiver-Operating Characteristic (ROC) curve. We included 455 clinical pregnancies (CP) obtained from 3387 COS-IUI cycles: 418 singletons, 35 twins, and 2 triplets. The CP, MP, and live birth rates were respectively 13.4%, 8.1% and 10.8%. The area under ROC curve for peak serum E₂ was 0.60 (0.52-0.69). The mean E₂ level was comparabl

SUBMITTER: Bouet PE 

PROVIDER: S-EPMC9666543 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature