Impact of CDKN2A/B, MTAP, and TERT Genetic Alterations on Survival in IDH Wild Type Glioblastomas.

ABSTRACT:

Purpose

Poor outcomes in IDH wild-type (IDHwt) glioblastomas indicate the need to determine which genetic alterations can indicate poor survival and guidance of patient specific treatment options. We sought to identify the genetic alterations in these patients that predict for survival when adjusting particularly for treatments and other genetic alterations.

Methods

A cohort of 167 patients with pathologically confirmed IDHwt glioblastomas treated at our institution was retrospectively reviewed. Next generation sequencing was performed for each patient to determine tumor genetic alterations. Multivariable cox proportional hazards analysis for overall survival (OS) was performed to control for patient variables.

Results

CDKN2A, CDKN2B, and MTAP deletion predict for wor

SUBMITTER: Hsu EJ 

PROVIDER: S-EPMC9666584 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature