Reciprocal best structure hits: using AlphaFold models to discover distant homologues.

ABSTRACT:

Motivation

The conventional methods to detect homologous protein pairs use the comparison of protein sequences. But the sequences of two homologous proteins may diverge significantly and consequently may be undetectable by standard approaches. The release of the AlphaFold 2.0 software enables the prediction of highly accurate protein structures and opens many opportunities to advance our understanding of protein functions, including the detection of homologous protein structure pairs.

Results

In this proof-of-concept work, we search for the closest homologous protein pairs using the structure models of five model organisms from the AlphaFold database. We compare the results with homologous protein pairs detected by their sequence similarity and show that the structural match

SUBMITTER: Monzon V 

PROVIDER: S-EPMC9666668 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature