NLRP3 inflammasome activation contributes to the cognitive decline after cardiac surgery.

ABSTRACT:

Background

Perioperative neurocognitive disorders (PND) are a common complication of cardiac surgery in elderly patients. The etiopathogenesis of PND is not clear. Nod-like receptor family pyrin domain containing 3 (NLRP3) inflammasome, a macromolecular protein complex, regulates inflammation by inducing the release of proinflammatory cytokines interleukin (IL)-1β and IL-18. Studies have demonstrated a close link between the NLRP3 inflammasome and central nervous system diseases. Nevertheless, the involvement of NLRP3 inflammasome in the causation of PND occurring after cardiac surgery is unclear. This study aimed to investigate the association of serum NLRP3 level with PND.

Methods

We performed a retrospective study, enrolled 75 patients undergoing elective cardiac surgery

SUBMITTER: Ma G 

PROVIDER: S-EPMC9666730 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature