Duration of initial prednisolone therapy for first episode of childhood nephrotic syndrome based on time to response.

ABSTRACT:

Background

The duration of initial corticosteroid therapy in newly diagnosed Idiopathic nephrotic syndrome (INS) is about 3 months. Our study was designed to test the feasibility of a shorter duration of corticosteroid therapy in newly diagnosed INS who show a quicker response.

Methods

Patients who responded within 10 days (Group A) received 8 weeks of corticosteroid therapy as compared to 12-14 weeks of standard therapy in those who responded between >10 days to 28 days (Group B), and follow up for 52 weeks. The primary endpoint is time to first relapse after treatment completion. (NCT03878914, March 18, 2019).

Results

A total of 33 children with INS were enrolled and the follow-up data were analyzed. The clinical and laboratory characteristics of patients in both gr

SUBMITTER: Tang X 

PROVIDER: S-EPMC9666732 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature