Alzheimer's disease alters the transcriptomic profile of natural killer cells at single-cell resolution.

ABSTRACT: Alzheimer's disease (AD) is the most common dementia without an effective cure at least partially due to incomplete understanding of the disease. Inflammation has emerged as a central player in the onset and progression of AD. As innate lymphoid cells, natural killer (NK) cells orchestrate the initiation and evolution of inflammatory responses. Yet, the transcriptomic features of NK cells in AD remain poorly understood. We assessed the diversity of NK cells using web-based single-cell RNA sequencing data of blood NK cells from patients with AD and control subjects and flow cytometry. We identified a contraction of NK cell compartment in AD, accompanied by a reduction of cytotoxicity. Unbiased clustering revealed four subsets of NK cells in AD, i.e., CD56^bright NK cells, CD56

SUBMITTER: Qi C 

PROVIDER: S-EPMC9666759 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature