Ontology highlight
ABSTRACT:
SUBMITTER: Shen Y
PROVIDER: S-EPMC9667049 | biostudies-literature | 2022
REPOSITORIES: biostudies-literature
Shen Yunfu Y Guo Kaiqiang K Ma Aijun A Huang Zhe Z Du Jingjing J Chen Junhe J Lin Qianyu Q Wei Chengming C Wang Zi Z Zhang Fuming F Zhang Juan J Lin Wanjun W Feng Na N Ma Wenzhe W
Frontiers in pharmacology 20221102
There are technical obstacles in the safety evaluation of traditional Chinese medicine (TCM) injections due to their complex chemical nature and the lack of rapid and accurate <i>in vitro</i> methods. Here, we established a dual <i>in vitro</i> mitochondrial toxicity approach combing the conventional "glucose/galactose" assay in HepG2 cells with the cytotoxic assay in mitochondrial respiration deficient cells. Using this dual <i>in vitro</i> approach, for the first time, we systematically assess ...[more]