Effect of empagliflozin on cytoskeletal repair in the hippocampus of obese mice.

ABSTRACT:

Objective

We aimed to investigate the effect of empagliflozin on hippocampal phosphorylated protein levels in obese mice.

Materials and methods

Sixteen obese mice successfully modeled on high-fat diet were randomly divided into high-fat feeding group (group H) and empagliflozin group (group H + empagliflozin, group E), eight mice in each group, and eight C57BL/6J male normal mice were selected as the control group (normal control, group C). Group E was treated with empagliflozin 10 mg/kg/d for 12 weeks, while mice in groups H and C were treated with equal amounts of saline. The spatial learning memory ability of the mice was determined by the Morris water maze experiment. Further, their body weights and serological indices were measured. Finally, total proteins were extracte

SUBMITTER: Chen X 

PROVIDER: S-EPMC9667058 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature