High-definition transcranial direct current stimulation enhances network segregation during spatial navigation in mild cognitive impairment.

ABSTRACT: Spatial navigation is essential for everyday life and relies on complex network-level interactions. Recent evidence suggests that transcranial direct current stimulation (tDCS) can influence the activity of large-scale functional brain networks. We characterized brain-wide changes in functional network segregation (i.e. the balance of within vs. between-network connectivity strength) induced by high-definition (HD) tDCS in older adults with mild cognitive impairment (MCI) during virtual spatial navigation. Twenty patients with MCI and 22 cognitively intact older adults (healthy controls-HC) underwent functional magnetic resonance imaging following two counterbalanced HD-tDCS sessions (one active, one sham) that targeted the right parietal cortex (center anode at P2) and delivered 2 mA for

SUBMITTER: Iordan AD 

PROVIDER: S-EPMC9667179 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature