Fulminant lung fibrosis in non-resolvable COVID-19 requiring transplantation.

ABSTRACT:

Background

Coronavirus Disease 2019 (COVID-19) can lead to the development of acute respiratory distress syndrome (ARDS). In some patients with non-resolvable (NR) COVID-19, lung injury can progress rapidly to the point that lung transplantation is the only viable option for survival. This fatal progression of lung injury involves a rapid fibroproliferative response and takes on average 15 weeks from initial symptom presentation. Little is known about the mechanisms that lead to this fulminant lung fibrosis (FLF) in NR-COVID-19.

Methods

Using a pre-designed unbiased PCR array for fibrotic markers, we analyzed the fibrotic signature in a subset of NR-COVID-19 lungs. We compared the expression profile against control lungs (donor lungs discarded for transplantation), and expla

SUBMITTER: Jyothula SSK 

PROVIDER: S-EPMC9667270 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature