H11-induced immunoprotection is predominantly linked to N-glycan moieties during Haemonchus contortus infection.

ABSTRACT: Nematodes are one of the largest groups of animals on the planet. Many of them are major pathogens of humans, animals and plants, and cause destructive diseases and socioeconomic losses worldwide. Despite their adverse impacts on human health and agriculture, nematodes can be challenging to control, because anthelmintic treatments do not prevent re-infection, and excessive treatment has led to widespread drug resistance in nematode populations. Indeed, many nematode species of livestock animals have become resistant to almost all classes of anthelmintics used. Most efforts to develop commercial anti-nematode vaccines (native or recombinant) for use in animals and humans have not succeeded, although one effective (dead) vaccine (Barbervax) has been developed to protect animals against one o

SUBMITTER: Wang C 

PROVIDER: S-EPMC9667387 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature