Preliminary studies on apparent mendelian psychotic disorders in consanguineous families.

ABSTRACT:

Background

Psychiatric disorders are characterized by alteration in emotions, mood and behavior. Genetics is known to play a significant role in the development of psychiatric disorders. Genome-wide association studies have identified several loci associated with psychiatric illnesses. We hypothesize the existence of rare variants following Mendelian recessive mode of inheritance. These variants can be identified in families with multiple affected individuals born to unaffected consanguineous parents.

Methods

We visited psychiatric outpatient departments of multiple hospitals in Lahore, Pakistan. We focused on psychosis, as it can occur in several DSM disorders such as schizophrenia, dementia and bipolar disorder. After clinical diagnosis by an American trained psychiatrist,

SUBMITTER: Kanwal A 

PROVIDER: S-EPMC9667425 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature