Beneficial effect of the short-chain fatty acid propionate on vascular calcification through intestinal microbiota remodelling.

ABSTRACT:

Background

Vascular calcification is a major cause of the high morbidity and mortality of cardiovascular diseases and is closely associated with the intestinal microbiota. Short-chain fatty acids (SCFAs) are derived from the intestinal microbiota and can also regulate intestinal microbiota homeostasis. However, it remains unclear whether exogenous supplementation with propionate, a SCFA, can ameliorate vascular calcification by regulating the intestinal microbiota. This study was conducted to explore the roles of propionate and the intestinal microbiota in the process of vascular calcification.

Methods

In total, 92 patients were enrolled consecutively as the observational cohort to analyse the relationship between SCFAs and vascular calcification in both blood and faecal sam

SUBMITTER: Yan J 

PROVIDER: S-EPMC9667615 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature