Bioinformatics tools and data resources for assay development of fluid protein biomarkers.

ABSTRACT: Fluid protein biomarkers are important tools in clinical research and health care to support diagnosis and to monitor patients. Especially within the field of dementia, novel biomarkers could address the current challenges of providing an early diagnosis and of selecting trial participants. While the great potential of fluid biomarkers is recognized, their implementation in routine clinical use has been slow. One major obstacle is the often unsuccessful translation of biomarker candidates from explorative high-throughput techniques to sensitive antibody-based immunoassays. In this review, we propose the incorporation of bioinformatics into the workflow of novel immunoassay development to overcome this bottleneck and thus facilitate the development of novel biomarkers towards clinical labor

SUBMITTER: Waury K 

PROVIDER: S-EPMC9667682 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature