Untargeted metabolomics identified kynurenine as a predictive prognostic biomarker in acute myocardial infarction.

ABSTRACT:

Objective

The occurrence of cardiovascular adverse events in the first year after ST-acute myocardial infarction (STEMI) remains high; therefore, identification of patients with poor prognosis is essential for early intervention. This study aimed to evaluate the prognostic value of metabolomics-based biomarkers in STEMI patients and explore their functional mechanisms.

Methods

Metabolite profiling was performed using nuclear magnetic resonance. The plasma concentration of Kynurenine (Kyn) was measured using ultraperformance liquid chromatography/electrospray ionization quadruple time-of-flight mass spectrometry. Major adverse cardiac and cerebral events were assessed for 1 year. A functional metabolomics strategy was proposed for investigating the role of Kyn in both vitro a

SUBMITTER: Zhang X 

PROVIDER: S-EPMC9667794 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature