Ligand-free nickel catalyzed perfluoroalkylation of arenes and heteroarenes.

ABSTRACT: We describe a "ligand-free" Ni-catalyzed perfluoroalkylation of heteroarenes to produce a diverse array of trfiluoromethyl, pentafluoroethyl and heptafluoropropyl adducts. Catalysis proceeds at room temperature via a radical pathway. The catalytic protocol is distinguished by its simplicity, and its wide scope demonstrates the potential in the late-stage functionalization of drug analogues and peptides.

SUBMITTER: Deolka S 

PROVIDER: S-EPMC9667918 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature