Enol-mediated delivery of H₂Se from γ-keto selenides: mechanistic insight and evaluation.

ABSTRACT: Like hydrogen sulfide (H₂S), its chalcogen congener, hydrogen selenide (H₂Se), is an emerging molecule of interest given its endogenous expression and purported biological activity. However, unlike H₂S, detailed investigations into the chemical biology of H₂Se are limited and little is known about its innate physiological functions, cellular targets, and therapeutic potential. The obscurity surrounding these fundamental questions is largely due to a lack of small molecule donors that can effectively increase the bioavailability of H₂Se through their continuous liberation of the transient biomolecule under physiologically relevant conditions. Driven by this unmet demand for H₂Se-releasing moieties, we report that γ-keto selen

SUBMITTER: Hankins RA 

PROVIDER: S-EPMC9667953 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature