Elf3 deficiency during zebrafish development alters extracellular matrix organization and disrupts tissue morphogenesis.

ABSTRACT: E26 transformation specific (ETS) family transcription factors are expressed during embryogenesis and are involved in various cellular processes such as proliferation, migration, differentiation, angiogenesis, apoptosis, and survival of cellular lineages to ensure appropriate development. Dysregulated expression of many of the ETS family members is detected in different cancers. The human ELF3, a member of the ETS family of transcription factors, plays a role in the induction and progression of human cancers is well studied. However, little is known about the role of ELF3 in early development. Here, the zebrafish elf3 was cloned, and its expression was analyzed during zebrafish development. Zebrafish elf3 is maternally deposited. At different developmental stages, elf3 expression was detec

SUBMITTER: Sarmah S 

PROVIDER: S-EPMC9668168 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature