Proteolysis and Deficiency of α1-Proteinase Inhibitor in SARS-CoV-2 Infection.

ABSTRACT: The SARS-CoV-2 pandemic had stimulated the emergence of numerous publications on the α₁-proteinase inhibitor (α₁-PI, α₁-antitrypsin), especially when it was found that the regions of high mortality corresponded to the regions with deficient α₁-PI alleles. By analogy with the data obtained in the last century, when the first cause of the genetic deficiency of α₁-antitrypsin leading to elastase activation in pulmonary emphysema was proven, it can be supposed that proteolysis hyperactivation in COVID-19 may be associated with the impaired functions of α₁-PI. The purpose of this review was to systematize the scientific data and critical directions for translational studies on the role of α₁-PI in SARS-CoV-2-induced pr

SUBMITTER: Akbasheva OE 

PROVIDER: S-EPMC9668222 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature