Tumour microbiota structure predicts hypopharyngeal carcinoma recurrence and metastasis.

ABSTRACT:

Objectives

The relationship between microbiota and HPSCC recurrence and metastasis remains uncertain. This study aimed to investigate the role of the tumour microbiota in the disease-free survival (DFS) of HPSCC patients.

Materials and methods

Formalin-fixed paraffin-embedded (FFPE) tumour tissues were collected from 103 patients with HPSCC for 16S rRNA sequencing. We analysed the tumour microbiota in HPSCC patients with recurrence/metastasis and nonrecurrence/metastasis. The linear predictor score (LPS) was calculated based on the Cox regression model to assess the risk of recurrence and metastasis. Then, a time-dependent ROC curve was used to evaluate the prognostic power of the LPS.

Results

The phyla Bacteroidota, Firmicutes and Proteobacteria were th

SUBMITTER: Yuan X 

PROVIDER: S-EPMC9668281 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature