Tripartite extended amygdala-basal ganglia CRH circuit drives locomotor activation and avoidance behavior.

ABSTRACT: An adaptive stress response involves various mediators and circuits orchestrating a complex interplay of physiological, emotional, and behavioral adjustments. We identified a population of corticotropin-releasing hormone (CRH) neurons in the lateral part of the interstitial nucleus of the anterior commissure (IPACL), a subdivision of the extended amygdala, which exclusively innervate the substantia nigra (SN). Specific stimulation of this circuit elicits hyperactivation of the hypothalamic-pituitary-adrenal axis, locomotor activation, and avoidance behavior contingent on CRH receptor type 1 (CRHR1) located at axon terminals in the SN, which originate from external globus pallidus (GPe) neurons. The neuronal activity prompting the observed behavior is shaped by IPACL^CRH and GPe

SUBMITTER: Chang S 

PROVIDER: S-EPMC9668302 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature