A prebiotic diet modulates microglial states and motor deficits in α-synuclein overexpressing mice.

ABSTRACT: Parkinson's disease (PD) is a movement disorder characterized by neuroinflammation, α-synuclein pathology, and neurodegeneration. Most cases of PD are non-hereditary, suggesting a strong role for environmental factors, and it has been speculated that disease may originate in peripheral tissues such as the gastrointestinal (GI) tract before affecting the brain. The gut microbiome is altered in PD and may impact motor and GI symptoms as indicated by animal studies, although mechanisms of gut-brain interactions remain incompletely defined. Intestinal bacteria ferment dietary fibers into short-chain fatty acids, with fecal levels of these molecules differing between PD and healthy controls and in mouse models. Among other effects, dietary microbial metabolites can modulate activation of microg

SUBMITTER: Abdel-Haq R 

PROVIDER: S-EPMC9668333 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature