The individuality of shape asymmetries of the human cerebral cortex.

ABSTRACT: Asymmetries of the cerebral cortex are found across diverse phyla and are particularly pronounced in humans, with important implications for brain function and disease. However, many prior studies have confounded asymmetries due to size with those due to shape. Here, we introduce a novel approach to characterize asymmetries of the whole cortical shape, independent of size, across different spatial frequencies using magnetic resonance imaging data in three independent datasets. We find that cortical shape asymmetry is highly individualized and robust, akin to a cortical fingerprint, and identifies individuals more accurately than size-based descriptors, such as cortical thickness and surface area, or measures of inter-regional functional coupling of brain activity. Individual identifiabilit

SUBMITTER: Chen YC 

PROVIDER: S-EPMC9668337 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature