Ontology highlight
ABSTRACT:
SUBMITTER: Gomez-Banuelos E
PROVIDER: S-EPMC9668488 | biostudies-literature | 2022 Aug
REPOSITORIES: biostudies-literature
Gómez-Bañuelos Eduardo E Konig Maximilian F MF Andrade Felipe F
Current opinion in structural biology 20220711
The specific association between antibodies to citrullinated proteins and rheumatoid arthritis (RA) has centered interest on understanding why citrullinated proteins become immunogenic in this disease, which is believed to inform the origins of autoimmunity in RA. Since citrullination is a physiologic post-translational modification (PTM), one theory is that conditions promoting abnormal citrullination are initiators of self-reactive immune responses to citrullinated proteins in RA. Foremost can ...[more]