Altered frequency-specific/universal amplitude characteristics of spontaneous brain oscillations in patients with bipolar disorder.

ABSTRACT: The human brain is a dynamic system with intrinsic oscillations in spontaneous neural activity. Whether the dynamic characteristics of these spontaneous oscillations are differentially altered across different frequency bands in patients with bipolar disorder (BD) remains unclear. This study recruited 65 patients with BD and 85 healthy controls (HCs). The entire frequency range of resting-state fMRI data was decomposed into four frequency intervals. Two-way repeated-measures ANCOVA was employed to detect frequency-specific/universal alterations in the dynamic oscillation amplitude in BD. The patients were then divided into two subgroups according to their mood states to explore whether these alterations were independent of their mood states. Finally, other window sizes, step sizes, and win

SUBMITTER: Zhang ZF 

PROVIDER: S-EPMC9668601 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature