White matter hyperintensity distribution differences in aging and neurodegenerative disease cohorts.

ABSTRACT:

Introduction

White matter hyperintensities (WMHs) are common magnetic resonance imaging (MRI) findings in the aging population in general, as well as in patients with neurodegenerative diseases. They are known to exacerbate the cognitive deficits and worsen the clinical outcomes in the patients. However, it is not well-understood whether there are disease-specific differences in prevalence and distribution of WMHs in different neurodegenerative disorders.

Methods

Data included 976 participants with cross-sectional T1-weighted and fluid attenuated inversion recovery (FLAIR) MRIs from the Comprehensive Assessment of Neurodegeneration and Dementia (COMPASS-ND) cohort of the Canadian Consortium on Neurodegeneration in Aging (CCNA) with eleven distinct diagnostic groups: cognitiv

SUBMITTER: Dadar M 

PROVIDER: S-EPMC9668605 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature