The longitudinal neural dynamics changes of whole brain connectome during natural recovery from poststroke aphasia.

ABSTRACT: Poststroke aphasia is one of the most dramatic functional deficits that results from direct damage of focal brain regions and dysfunction of large-scale brain networks. The reconstruction of language function depends on the hierarchical whole-brain dynamic reorganization. However, investigations into the longitudinal neural changes of large-scale brain networks for poststroke aphasia remain scarce. Here we characterize large-scale brain dynamics in left-frontal-stroke aphasia through energy landscape analysis. Using fMRI during an auditory comprehension task, we find that aphasia patients suffer serious whole-brain dynamics perturbation in the acute and subacute stages after stroke, in which the brains were restricted into two major activity patterns. Following spontaneous recovery process

SUBMITTER: Fan L 

PROVIDER: S-EPMC9668607 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature