Drug repurposing in psoriasis, performed by reversal of disease-associated gene expression profiles.

ABSTRACT: Psoriasis is a skin disease which results in scales on the skin caused by flaky patches. Psoriasis is triggered by various conditions such as drug reactions, trauma, and skin infection etc. Globally, there are 125 million people affected by psoriasis and yet there is no effective treatment available, and it emphasizes the need for discovery of efficacious treatments. De-novo drug development takes 10-17 years and $2-$3 billion of investment with <10 % success rate to bring drug from concept to a market ready product. A possible alternative is drug repurposing, which aims at finding other indications of already approved drugs. In this study, a computational drug repurposing framework is developed and applied to differential gene expressions of Psoriasis targets obtained from the publicly av

SUBMITTER: Ahmed F 

PROVIDER: S-EPMC9668643 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature