Frequency-dependent white-matter functional network changes associated with cognitive deficits in subcortical vascular cognitive impairment.

ABSTRACT: Vascular cognitive impairment (VCI) refers to all forms of cognitive decline associated with cerebrovascular diseases, in which white matter (WM) is highly vulnerable. Although previous studies have shown that blood oxygen level-dependent (BOLD) signals inside WM can effectively reflect neural activities, whether WM BOLD signal alterations are present and their roles underlying cognitive impairment in VCI remain largely unknown. In this study, 36 subcortical VCI (SVCI) patients and 36 healthy controls were enrolled to evaluate WM dysfunction. Specifically, fourteen distinct WM networks were identified from resting-state functional MRI using K-means clustering analysis. Subsequently, between-network functional connectivity (FC) and within-network BOLD signal amplitude of WM networks were ca

SUBMITTER: Ma J 

PROVIDER: S-EPMC9668649 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature