Neural function underlying reward expectancy and attainment in adolescents with diverse psychiatric symptoms.

ABSTRACT: Reward dysfunction has been hypothesized to play a key role in the development of psychiatric conditions during adolescence. To help capture the complexity of reward function in youth, we used the Reward Flanker fMRI Task, which enabled us to examine neural activity during expectancy and attainment of both certain and uncertain rewards. Participants were 84 psychotropic-medication-free adolescents, including 67 with diverse psychiatric conditions and 17 healthy controls. Functional MRI used high-resolution acquisition and high-fidelity processing techniques modeled after the Human Connectome Project. Analyses examined neural activation during reward expectancy and attainment, and their associations with clinical measures of depression, anxiety, and anhedonia severity, with results controll

SUBMITTER: Liu Q 

PROVIDER: S-EPMC9668660 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature