Common gray matter loss in the frontal cortex in patients with methamphetamine-associated psychosis and schizophrenia

ABSTRACT:

Background and hypothesis

Methamphetamine (MA)-associated psychosis has become a public concern. However, its mechanism is not clear. Investigating similarities and differences between MA-associated psychosis and schizophrenia in brain alterations would be informative for neuropathology.

Study design

This study compared gray matter volumes of the brain across four participant groups: healthy controls (HC, n = 53), MA users without psychosis (MA, n = 22), patients with MA-associated psychosis (MAP, n = 34) and patients with schizophrenia (SCZ, n = 33). Clinical predictors of brain alterations, as well as association of brain alterations with psychotic symptoms and attention impairment were further investigated.

Study results

Compared with the HC, the MAP and the S

SUBMITTER: Jia X 

PROVIDER: S-EPMC9668661 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature