Associations between abdominal adipose tissue, reproductive span, and brain characteristics in post-menopausal women.

ABSTRACT: The menopause transition involves changes in oestrogens and adipose tissue distribution, which may influence female brain health post-menopause. Although increased central fat accumulation is linked to risk of cardiometabolic diseases, adipose tissue also serves as the primary biosynthesis site of oestrogens post-menopause. It is unclear whether different types of adipose tissue play diverging roles in female brain health post-menopause, and whether this depends on lifetime oestrogen exposure, which can have lasting effects on the brain and body even after menopause. Using the UK Biobank sample, we investigated associations between brain characteristics and visceral adipose tissue (VAT) and abdominal subcutaneous adipose tissue (ASAT) in 10,251 post-menopausal females, and assessed whether

SUBMITTER: Schindler LS 

PROVIDER: S-EPMC9668664 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature