Spatiotemporal patterns of putaminal dopamine processing in Parkinson's disease: A multi-tracer positron emission tomography study.

ABSTRACT: Alterations in different aspects of dopamine processing may exhibit different progressive behaviours throughout the course of Parkinson's disease. We used a novel data-driven multivariate approach to quantify and compare spatiotemporal patterns related to different aspects of dopamine processing from cross-sectional Parkinson's subjects obtained with: 1) 69 [¹¹C]±dihydrotetrabenazine (DTBZ) scans, most closely related to dopaminergic denervation; 2) 73 [¹¹C]d-threo-methylphenidate (MP) scans, marker of dopamine transporter density; 3) 50 6-[¹⁸F]fluoro-l-DOPA (FD) scans, marker of dopamine synthesis and storage. The anterior-posterior gradient in the putamen was identified as the most salient feature associated with disease progression, however the temporal

SUBMITTER: Fu JF 

PROVIDER: S-EPMC9668665 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature