Medial temporal lobe and obstructive sleep apnea: Effect of sex, age, cognitive status and free-water.

ABSTRACT: Medial temporal structures, namely the hippocampus, the entorhinal cortex and the parahippocampal gyrus, are particularly vulnerable to Alzheimer's disease and hypoxemia. Here, we tested the associations between obstructive sleep apnea (OSA) severity and medial temporal lobe volumes in 114 participants aged 55-86 years (35 % women). We also investigated the impact of sex, age, cognitive status, and free-water fraction correction on these associations. Increased OSA severity was associated with larger hippocampal and entorhinal cortex volumes in women, but not in men. Greater OSA severity also correlated with increased hippocampal volumes in participants with amnestic mild cognitive impairment, but not in cognitively unimpaired participants, regardless of sex. Using free-water corrected vol

SUBMITTER: Martineau-Dussault ME 

PROVIDER: S-EPMC9668668 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature