Inferring the dynamical effects of stroke lesions through whole-brain modeling.

ABSTRACT: Understanding the effect of focal lesions (stroke) on brain structure-function traditionally relies on behavioral analyses and correlation with neuroimaging data. Here we use structural disconnection maps from individual lesions to derive a causal mechanistic generative whole-brain model able to explain both functional connectivity alterations and behavioral deficits induced by stroke. As compared to other models that use only the local lesion information, the similarity to the empirical fMRI connectivity increases when the widespread structural disconnection information is considered. The presented model classifies behavioral impairment severity with higher accuracy than other types of information (e.g.: functional connectivity). We assessed topological measures that characterize the func

SUBMITTER: Idesis S 

PROVIDER: S-EPMC9668672 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature