Entorhinal cortex directs learning-related changes in CA1 representations.

ABSTRACT: Learning-related changes in brain activity are thought to underlie adaptive behaviours^1,2. For instance, the learning of a reward site by rodents requires the development of an over-representation of that location in the hippocampus^3-6. How this learning-related change occurs remains unknown. Here we recorded hippocampal CA1 population activity as mice learned a reward location on a linear treadmill. Physiological and pharmacological evidence suggests that the adaptive over-representation required behavioural timescale synaptic plasticity (BTSP)⁷. BTSP is known to be driven by dendritic voltage signals that we proposed were initiated by input from entorhinal cortex layer 3 (EC3). Accordingly, the CA1 over-representation was largely removed by optogenetic in

SUBMITTER: Grienberger C 

PROVIDER: S-EPMC9668747 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature