Clinical applicability of quantitative atrophy measures on MRI in patients suspected of Alzheimer's disease.

ABSTRACT:

Objectives

Neurodegeneration in suspected Alzheimer's disease can be determined using visual rating or quantitative volumetric assessments. We examined the feasibility of volumetric measurements of gray matter (GMV) and hippocampal volume (HCV) and compared their diagnostic performance with visual rating scales in academic and non-academic memory clinics.

Materials and methods

We included 231 patients attending local memory clinics (LMC) in the Netherlands and 501 of the academic Amsterdam Dementia Cohort (ADC). MRI scans were acquired using local protocols, including a T1-weighted sequence. Quantification of GMV and HCV was performed using FSL and FreeSurfer. Medial temporal atrophy and global atrophy were assessed with visual rating scales. ROC curves were derived to deter

SUBMITTER: Ingala S 

PROVIDER: S-EPMC9668763 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature