Anterior chamber enhancement predicts optic nerve infiltration in retinoblastoma.

ABSTRACT:

Objectives

As described recently, intravenously injected gadolinium-based contrast agent (GBCA) penetrates into the anterior eye chamber (AC) and is drained from the retina to the distal optic nerve (ON) along perivascular spaces, which serves retinal homeostasis and was termed the orbital glymphatic system (GS). Independently, AC enhancement predicted ON infiltration, a major risk factor for advanced retinoblastoma (RB), in a small RB patient cohort. We aimed to review the supposed imaging biomarker for ON infiltration in a large RB cohort and with respect to the recently described orbital GS.

Methods

This IRB-approved retrospective single-center study encompassed 539 orbital MRIs performed with an orbital coil and with the children under general anesthesia. Differences of

SUBMITTER: Deike-Hofmann K 

PROVIDER: S-EPMC9668776 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature