Plasma proteomic characterization of the development of acute kidney injury in early sepsis patients.

ABSTRACT: Acute kidney injury (AKI) develops frequently in the course of patients with sepsis and strongly associates with in-hospital mortality. However, diagnosing AKI involves a considerable lag-time because it depends on assessing an increase in serum creatinine, and offers no insight in the underlying pathophysiology. Consequently, identifying a set of proteins reflecting the development of AKI may improve earlier recognition of AKI and the understanding of its pathophysiology. A targeted plasma proteomic approach was performed in early sepsis patients with and without subsequent AKI development in a matched pair design (n = 19 each). Principal component analysis identified 53 proteins associated with development of AKI, which were further analysed using Enrichr gene ontology and pathway analys

SUBMITTER: Star BS 

PROVIDER: S-EPMC9668831 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature