Integrative network analysis interweaves the missing links in cardiomyopathy diseasome.

ABSTRACT: Cardiomyopathies are progressive disease conditions that give rise to an abnormal heart phenotype and are a leading cause of heart failures in the general population. These are complex diseases that show co-morbidity with other diseases. The molecular interaction network in the localised disease neighbourhood is an important step toward deciphering molecular mechanisms underlying these complex conditions. In this pursuit, we employed network medicine techniques to systematically investigate cardiomyopathy's genetic interplay with other diseases and uncover the molecular players underlying these associations. We predicted a set of candidate genes in cardiomyopathy by exploring the DIAMOnD algorithm on the human interactome. We next revealed how these candidate genes form association across

SUBMITTER: Chauhan PK 

PROVIDER: S-EPMC9668833 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature