The progressive ratio and fixed ratio 1 schedules of cocaine self-administration in rats convey the same information.

ABSTRACT: Progressive ratio (PR) schedules of drug delivery are used to determine the 'motivational' state of an animal and drug 'reinforcing efficacy'. This widely held interpretation is supported mainly by the observation that the PR breakpoint (BP) is proportional to the unit dose of self-administered drug. The compulsion zone theory of cocaine self-administration was applied to determine whether it can explain the pattern of lever-pressing behavior and cocaine injections under the PR schedule in rats. This theory states that cocaine induces lever pressing when levels are below the satiety threshold and above the priming/remission threshold. Rats were trained to self-administer cocaine on a fixed ratio FR1 schedule over a range of cocaine unit doses. Then they were switched to a PR schedule. Typi

SUBMITTER: Tsibulsky VL 

PROVIDER: S-EPMC9668967 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature