Microfluidic vortex focusing for high throughput synthesis of size-tunable liposomes.

ABSTRACT: Control over vesicle size during nanoscale liposome synthesis is critical for defining the pharmaceutical properties of liposomal nanomedicines. Microfluidic technologies capable of size-tunable liposome generation have been widely explored, but scaling these microfluidic platforms for high production throughput without sacrificing size control has proven challenging. Here we describe a microfluidic-enabled process in which highly vortical flow is established around an axisymmetric stream of solvated lipids, simultaneously focusing the lipids while inducing rapid convective and diffusive mixing through application of the vortical flow field. By adjusting the individual buffer and lipid flow rates within the system, the microfluidic vortex focusing technique is capable of generating liposom

SUBMITTER: Han JY 

PROVIDER: S-EPMC9668976 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature