RasGRP1 promotes the acute inflammatory response and restricts inflammation-associated cancer cell growth.

ABSTRACT: An acute inflammatory response needs to be properly regulated to promote the elimination of pathogens and prevent the risk of tumorigenesis, but the relevant regulatory mechanism has not been fully elucidated. Here, we report that Ras guanine nucleotide-releasing protein 1 (RasGRP1) is a bifunctional regulator that promotes acute inflammation and inhibits inflammation-associated cancer. At the mRNA level, Rasgrp1 activates the inflammatory response by functioning as a competing endogenous RNA to specifically promote IL-6 expression by sponging let-7a. In vivo overexpression of the Rasgrp1 3' untranslated region enhances lipopolysaccharide-induced systemic inflammation and dextran sulphate sodium-induced colitis in Il6^+/+ mice but not in Il6^-/- mice. At the protein lev

SUBMITTER: Wang C 

PROVIDER: S-EPMC9669001 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature